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FOUNDERS PUBLICATIONS

Computational Drug Discovery

Biological Databases & Platforms

Biological Databases & Platforms

 Potshangbam AM, Nandeibam A, Amom T, Potshangbam N, Rahaman H, Rathore RS, Singh LR, Khan A. An in silico approach to identify potential medicinal plants for treating Alzheimer disease: a case study with acetylcholinesterase. Journal of Biomolecular Structure and Dynamics. 2022 Mar 4;40(4):1521-33. 


Potshangbam AM, Nongdam P, Kumar AK, Rathore RS. Phenylbenzopyrone of flavonoids as a potential scaffold to prevent SARSCoV-2 replication by inhibiting its MPRO main protease. Current Pharmaceutical Biotechnology. 2021 Dec 1;22(15):2054-70. 


 Potshangbam AM, Tanneeru K, Reddy BM, Guruprasad L. 3D-QSAR and molecular docking studies of 2-pyrimidinecarbonitrile derivatives as inhibitors against falcipain-3. Bioorganic & medicinal chemistry letters. 2011 Dec 1;21(23):7219-23. 


Damuka N, Kammari K, Potshangbam AM, Rathore RS, Kondapi AK, Vindal V. Discovery of dual cation-π inhibitors of acetylcholinesterase: design, synthesis and biological evaluation. Pharmacological Reports. 2020 Jun;72(3):705-18. 


 Ahmad MI, Potshangbam AM, Javed M, Ahmad M. Studies on conformational changes induced by binding of pendimethalin with human serum albumin. Chemosphere. 2020 Mar 1;243:125270. 


 Meetei PA, Rathore RS, Prabhu NP, Vindal V. In silico screening for identification of novel β-1, 3-glucan synthase inhibitors using pharmacophore and 3D-QSAR methodologies. Springerplus. 2016 Jul 4;5(1):965.  

Biological Databases & Platforms

Biological Databases & Platforms

Biological Databases & Platforms

Meetei PA, Singh P, Nongdam P, Prabhu NP, Rathore RS, Vindal V. NeMedPlant: a database of therapeutic applications and chemical constituents of medicinal plants from north-east region of India. Bioinformation. 2012 Feb 28;8(4):209. 


Potshangbam AM, Polavarapu R, Rathore RS, Naresh D, Prabhu NP, Potshangbam N, Kumar P, Vindal V. Med PS erver: A database for identification of therapeutic targets and novel leads pertaining to natural products. Chemical Biology & Drug Design. 2019 Apr;93(4):438-46. 

Network-Pharmacology

Biological Databases & Platforms

Natural Product Research

 Jakhmola-Mani R, Islam A, Katare DP. Liver-brain axis in sporadic Alzheimer’s disease: Role of ten signature genes in a mouse model. CNS & Neurological Disorders-Drug Targets-CNS & Neurological Disorders). 2021 Nov 1;20(9):871-85. 


  Jakhmola-Mani R, Sharma V, Singh S, Allen T, Dogra N, Katare DP. Drug Repurposing and Molecular Insights in the Fight Against Breast Cancer. Biomedical and Pharmacology Journal. 2024 Jun 25;17(2):831-61. 


 Dogra N, Mani RJ, Katare DP. Protein interaction studies for understanding the tremor pathway in Parkinson’s disease. CNS & Neurological Disorders-Drug Targets-CNS & Neurological Disorders). 2020 Dec 1;19(10):780-90. 


Mittal K, Mani RJ, Katare DP. Type 3 diabetes: Cross talk between differentially regulated proteins of type 2 diabetes mellitus and Alzheimer’s disease. Scientific reports. 2016 May 6;6(1):25589. 


 Agarwal K, Katare DP, Jakhmola-Mani R. Foresee novel targets for Alzheimer’s disease by investigating repurposed drugs. CNS & Neurological Disorders-Drug Targets-CNS & Neurological Disorders). 2023 Oct 1;22(8):1209-31. 


Dogra N, Jakhmola-Mani R, Potshangbam AM, Buch S, Pande Katare D. CXCR4 as possible druggable target linking inflammatory bowel disease and Parkinson's disease. Metabolic Brain Disease. 2023 Mar;38(3):1079-96. 


 Jakhmola Mani R, Sehgal N, Dogra N, Saxena S, Pande Katare D. Deciphering underlying mechanism of Sars-CoV-2 infection in humans and revealing the therapeutic potential of bioactive constituents from Nigella sativa to combat COVID19: in-silico study. Journal of Biomolecular Structure and Dynamics. 2022 Apr 13;40(6):2417-29. 


 Mani RJ, Mittal K, Mishra S, Kharkwal H, Ahmad S, Katare DP. In Silico Approach to Evaluate the Efficacy of Dietary Flavonoids and Their Role in Alzheimer's Disease. International Journal of Pharmaceutical Sciences Review an d Research. 2015;34:94-102. 


 Mani RJ, Katare DP. Molecular Mechanisms behind Initiation of Focal Seizure in Temporal Lobe Epilepsy: Computational Study. InNeurodegenerative Diseases-Molecular Mechanisms and Current Therapeutic Approaches 2020 Jun 19. IntechOpen. 

Natural Product Research

Artificial Intelligence & Computational Biology

Natural Product Research

 Mani RJ, Mittal K, Katare DP. Protective effects of quercetin in zebrafish model of Alzheimer’s disease. Asian J Pharm. 2018 Apr 1;12(2):660-6. 


 Chaturvedi A, Tiwari AK, Mani RJ. Traditional practices of using various medicinal plants during postnatal care in Chitrakoot district. Indian Journal of Traditional Knowledge. 2017 Oct 1;16(4):605-13. 


 Yadav R, Mani RJ, Sharma A, Kumar A, Katare D. Formulation and optimization of metformin-berberine loaded solid lipid nanoparticles for their neuroprotective effects in the brain. Journal of Applied Pharmaceutical Research. 2025 Oct 31;13(5):114-33. 

Artificial Intelligence & Computational Biology

Artificial Intelligence & Computational Biology

Artificial Intelligence & Computational Biology

Mani RJ, Lalwani H, Potshangbam AM, Rani S, Katare K, Chauhan A. Building a Knowledge Network of Drug-Drug Interactions Using Natural Language Processing and Graph Databases: Drug-Drug Interaction and Graph Networks. InApplications of Artificial Intelligence in Pharmaceuticals 2026 (pp. 389-422). IGI Global Scientific Publishing. 


Mani RJ, Bora BR, Amin N, Garg M, Vanam K, Bhattacharjee SD. AI Driven Pharmacovigilance Case Study: Predicting Adverse Effects of Drugs Using NLP and Patient Feedback. InApplications of Artificial Intelligence in Pharmaceuticals 2026 (pp. 357-388). IGI Global Scientific Publishing. 


  Jakhmola‐Mani R, Sonali, Pandey A, Raturi D, Singh R, Vanam K, Chauhan R, Katare DP, Nongdam P, Potshangbam AM. Exploring Machine Learning Algorithms for Gene Function Prediction in Crops. Bioinformatics for Plant Research and Crop Breeding. 2024 Nov 22:159-83. 


Mathew BB, Vajha VK, Mani RJ. Data Science for Threat Detection and Analysis. Cybersecurity Unlocked: Cryptography, Network Security, Data Protection. 2025 Dec 15:59. 


 Vajha VK, Mathew BB, Mani RJ. Emerging Cyber Threats: Challenges, Impacts, and Proactive Defenses in the Digital Age. Cybersecurity Unlocked: Cryptography, Network Security, Data Protection. 2025 Dec 15:1. 


 Mani RJ, Singh S, Sonu S, Katare DP. Tech-Driven Harvest: Blockchain's Role in Sustainable Food Systems and Waste-Free Future. InBlockchain and Digital Twin Applications in Smart Agriculture 2025 Apr 17 (pp. 215-236). Auerbach Publications. 


 Mani RJ, Masood S, Bhalerao P, Katare DP. Smarter Yields, Sustainable Practices: Predictive Modelling for Informed Decision Making in Smart Farming. InBlockchain and Digital Twin Applications in Smart Agriculture 2025 Apr 17 (pp. 192-214). Auerbach Publications. 


 Mani RJ, Kapoor N, Kashyap H, Shukla A, Katare DP. AI-Enabled Blockchain for Livestock Tracking and Health Management in Smart Agriculture. InBlockchain and Digital Twin Applications in Smart Agriculture 2025 Apr 17 (pp. 52-68). Auerbach Publications. 


  Ali YA, Pathak P, Dogra N, Potshangbam AM, Tuteja S, Katare DP, Bhattacharjee SD, Hussain MA, Mani RJ. Exploring the Role of Natural Learning Processing in Alzheimer's Disease Research and Prediction. InAI-Driven Alzheimer's Disease Detection and Prediction 2024 (pp. 419-432). IGI Global Scientific Publishing. 


 Singh R, Dogra N, Yadav R, Potshangbam AM, Katare DP, Mani RJ. Digital Histopathology: Paving Future Directions Towards Predicting Diagnosis of Disease Via Image Analysis. InHandbook of AI-Based Models in Healthcare and Medicine 2024 Feb 21 (pp. 347-377). CRC Press. 


 Singh TV, Dogra N, Saxena A, Katare DP, Mani RJ. Critical Analysis of Current Healthcare Applications for Diagnosis of Diseases: Pitfalls and Future. InHandbook of AI-Based Models in Healthcare and Medicine 2024 Feb 21 (pp. 303-329). CRC Press. 


Chauhan R, Mishra A, Mani RJ, Yafi E, Zuhairi MF. An analytical paradigm for exploration of diabetes using machine learning. In2025 19th International Conference on Ubiquitous Information Management and Communication (IMCOM) 2025 Jan 3 (pp. 1-8). IEEE. 


 Kumari R, Aggarwal N, Mani RJ, Bansal H. Machine Learning and Computational Models for the Prediction of Post-Translational Modification Sites. InComputational Techniques for Biological Sequence Analysis 2025 (pp. 1-33). CRC Press. 


 Borah NK, Tripathi Y, Tanwar A, Tiwari D, Sinha A, Sharma S, Jabalia N, Mani RJ, Santoshi S, Bansal H. Artificial Intelligence‐Powered Molecular Docking: A Promising Tool for Rational Drug Design. Artificial Intelligence and Machine Learning in Drug Design and Development. 2024 Jul 12:157-88. 

Medicine

Artificial Intelligence & Computational Biology

Artificial Intelligence & Computational Biology

 Vollset SE, Ababneh HS, Abate YH, Abbafati C, Abbasgholizadeh R, Abbasian M, Abbastabar H, Abd Al Magied AH, Abd ElHafeez S, Abdelkader A, Abdelmasseh M, Ruchi Jakhmola-Mani. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021. The Lancet. 2024 May 18;403(10440):2204-56. 


 R Yi Deun Jeong&, Seoyoung Park&, Wonwoo Jang&, Min Seo Kim&, Jakhmola-Mani and GBD 2021 AEMT Collaborators. Global burden of adverse effects of medical treatment from 1990 to 2021: a Global Burden of Disease Study 2021. The Korean Journal of Internal Medicine. 2026 Mar 1;41(2):350. 

Molecular Biology & Protein Science

Plant Biotechnology & Conservation Genomics

Plant Biotechnology & Conservation Genomics

 Jakhmola Mani R, Dogra N, Katare DP. The connection between chronic liver damage and sporadic Alzheimer’s disease: evidence and insights from a rat model. Brain Sciences. 2023 Sep 29;13(10):1391. 


 Kalueff AV, Echevarria DJ, Homechaudhuri S, Stewart AM, Collier AD, Kaluyeva AA, Li S, Liu Y, Chen P, Wang J, Yang L. Zebrafish neurobehavioral phenomics for aquatic neuropharmacology and toxicology research. Aquatic Toxicology. 2016 Jan 1;170:297-309. 


 P. Katare D, Malik S, J. Mani R, Ranjpour M, Jain SK. Novel mutations in transthyretin gene associated with hepatocellular carcinoma. Molecular Carcinogenesis. 2018 Jan;57(1):70-7. 


 Asad M, Wajid S, Katare DP, Mani RJ, Jain SK. Differential expression of TOM34, AL1A1, PADI2 and KLRBA in NNK induced lung cancer in wistar rats and their implications. Current Cancer Drug Targets. 2019 Dec 1;19(11):919-29. 


 Yadav R, Mani RJ, Sharma A, Kumar A, Katare D. Formulation and optimization of metformin-berberine loaded solid lipid nanoparticles for their neuroprotective effects in the brain. Journal of Applied Pharmaceutical Research. 2025 Oct 31;13(5):114-33. 

Plant Biotechnology & Conservation Genomics

Plant Biotechnology & Conservation Genomics

Plant Biotechnology & Conservation Genomics

 Amom T, Tikendra L, Potshangbam AM, Bidyananda N, Devi RS, Dey A, Sahoo MR, Vendrame WA, Jamir I, Nongdam P. Conservation strategies for endemic Dendrocalamus manipureanus: A study on genetic diversity and population structure based on molecular and phytochemical markers. South African Journal of Botany. 2023 Jan 1;152:106-23. 


 Tikendra L, Apana N, Potshangbam AM, Amom T, Choudhary R, Sanayaima R, Dey A, Nongdam P. Dendrobium sp.: in vitro propagation of genetically stable plants and ethnomedicinal uses. InOrchids Phytochemistry, Biology and Horticulture: Fundamentals and Applications 2022 Jan 24 (pp. 453-493). Cham: Springer International Publishing. 


 Tikendra L, Sushma O, Amom T, Devi NA, Paonam S, Bidyananda N, Potshangbam AM, Dey A, Devi RS, Nongdam P. Genetic clonal fidelity assessment of rhizome-derived micropropagated Acorus calamus L.–a medicinally important plant by random amplified polymorphic DNA and inter-simple sequence repeat markers. Pharmacognosy Magazine. 2022 Jan 1;18(77):207-15. 


 Apana N, Amom T, Tikendra L, Potshangbam AM, Dey A, Nongdam P. Genetic diversity and population structure of Clerodendrum serratum (L.) Moon using CBDP, iPBS and SCoT markers. Journal of Applied Research on Medicinal and Aromatic Plants. 2021 Dec 1;25:100349. 


 Tikendra L, Choudhary R, Sanayaima Devi R, Dey A, Potshangbam AM, Nongdam P. Micropropagation of bamboos and clonal fidelity assessment using molecular markers. InBiotechnological advances in Bamboo: The “Green Gold” on the earth 2021 Aug 30 (pp. 145-185). Singapore: Springer Singapore. 


 Damuka N, Kammari K, Potshangbam AM, Kondapi AK, Vindal V. Epoxydicoumarin Derivative is a Novel Non‐Nucleoside TLR8 Agonist: Screening, Synthesis and Biological Evaluation. ChemistrySelect. 2021 Jun 28;6(24):5941-8. 


 Tikendra L, Potshangbam AM, Amom T, Dey A, Nongdam P. Understanding the genetic diversity and population structure of Dendrobium chrysotoxum Lindl.-An endangered medicinal orchid and implication for its conservation. South African Journal of Botany. 2021 May 1;138:364-76. 


 Tikendra L, Potshangbam AM, Dey A, Devi TR, Sahoo MR, Nongdam P. RAPD, ISSR, and SCoT markers based genetic stability assessment of micropropagated Dendrobium fimbriatum Lindl. var. oculatum Hk. f.-an important endangered orchid. Physiology and Molecular Biology of Plants. 2021 Feb;27(2):341-57. 


 Amom T, Tikendra L, Apana N, Goutam M, Sonia P, Koijam AS, Potshangbam AM, Rahaman H, Nongdam P. Efficiency of RAPD, ISSR, iPBS, SCoT and phytochemical markers in the genetic relationship study of five native and economical important bamboos of North-East India. Phytochemistry. 2020 Jun 1;174:112330. 


 Shahnaj S, Potshangbam AM, Chowhan RK, Parray ZA, Kakchingtabam P, Kumari A, Islam A, Khan A, Singh LR, Rahaman H. The anti-oxidant enzyme, Prdx6 might have cis-acting regulatory sequence (s). International journal of biological macromolecules. 2020 Apr 15;149:1139-50. 

Founders' Innovation Portfolio

Patents

Copyrights

Copyrights

Rivastigmine and Quercetin conjugate form for treatment of Alzheimer’s disease. 2414/DEL/2013. Published


Tacrine and Quercetin conjugate form for treatment of Alzheimer’s disease. 2897/DEL/2013. GRANTED- March      2020


Filomicelles of combination drugs for the treatment of Brain Diabetes. E-101/8929/2017-DEL. GRANTED- Feb 2023


Molecular interactions of hepatocellular carcinoma specific proteins in transgenic and chemically induced animal model. 201811045271A. Published


SOLID LIPID FORMULATION OF METFORMIN AND BERBERINE FOR ENHANCED NEUROPROTECTIVE EFFECTS AND PREPARATION METHOD  THEREOF’.  Published


A novel Phytochemical based skin rejuvenation nano formulation cream and preparation method thereof. 202311070167. Published. 


Method for Enhancing Lipid Production in  Bacterial strain Using Xylose for Biodiesel Applications. Filed. 27th September  2024. 

Copyrights

Copyrights

Copyrights

 Public health Alert system in India: Utilizing social media and News for early detection. 21564/2024-CO/L. Granted


Transforming brain tumor diagnosis with cutting-edge machine learning Models. 21565/2024-CO/L. Granted


Image-Based Pathogen Detection in Clinical Samples using Artificial Intelligence based algorithms. 2025. Filed.      

ALGOBIOME PUBLICATIONS

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ALGOBIOMES' Innovation Portfolio

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